Vet product

Tolfedine (Tolfenamic acid) Dose for Dogs & Cats: Strengths & Dose Calculator

Reviewed by Dr. Ravi Baraiya, B.V.Sc.Updated 2 Nov 20262 sources

Tolfedine is tolfenamic acid from Vetoquinol; the 4% injection holds 40 mg/mL ^[1]. Dogs with hip-dysplasia osteoarthritis get 4 mg/kg by injection then tablets for 2–4 more days; cats with fever get 4 mg/kg a day by mouth for 3–5 days ^[1].

Contains: Tolfenamic acid
Company: Vetoquinol
Forms: Tolfedine 4% injection (40 mg/mL)
Label species: Dogs, Cats
Data from: Canada
Type: NSAID / pain relief

Tolfedine dose calculator

Results are calculated in your browser from the doses and strengths on this page. Check the strength printed on your pack and the label in your country before giving any dose.

Tolfedine strengths and presentations

Presentation	Contains	Strength check
Tolfedine 4% injection (40 mg/mL) SC / IM	Tolfenamic acid 40 mg per mL^[1]	Confirmed

Tolfedine dose by species

Species	Use	Dose	Route	How often	Basis
Dogs	Osteoarthritis (hip dysplasia)	4 mg/kg^[1]	SC or IM, then tablets	Once daily · Injection, then tablets 2–4 more days; may be repeated weekly	Label
Cats	Fever	4 mg/kg^[1]	PO	Once daily · 3–5 days	Label

Label directions

Dogs: 4 mg/kg SC or IM, then Tolfedine tablets at the same dose for 2–4 more days; may be repeated once a week ^[1].
Cats: 4 mg/kg by mouth once a day for 3–5 days ^[1].

Warnings and precautions

Contraindicated with gastro-duodenal ulcers or severe kidney, heart or liver disorders ^[1].
Contraindicated in dehydrated, hypovolaemic or hypotensive animals ^[1].
Not advised in breeding, pregnant or lactating animals ^[1].

About tolfenamic acid (the active ingredient)

Non-steroidal anti-inflammatory drug (NSAID, fenamate).

How it works

NSAIDs reduce prostaglandin production by inhibiting the cyclooxygenase (COX) enzymes ^[2].

Key safety points

Contraindicated with gastro-duodenal ulcers or severe kidney, heart or liver disorders, and in dehydrated, hypovolaemic or hypotensive animals ^[1].
NSAIDs carry more risk in animals under 6 weeks old and in aged, debilitated or sick animals ^[1].

All about tolfenamic acid — doses by species and every brand →

Pack sizes

Injection: 30 mL bottles ^[1].

Frequently asked questions

What is the Tolfedine dose for dogs?

4 mg/kg of tolfenamic acid by injection, then tablets at the same dose for 2–4 more days ^[1].

More from Vetoquinol

CimicoxibCimalgex

All veterinary products →

Tolfedine is a trademark of its owner. This page is an independent clinical reference and is not affiliated with Vetoquinol. Strengths, species and withdrawal periods can differ between countries — always follow the pack insert in your country.

Have a case in front of you?Ask WeVet — the AI assistant built for veterinarians. Differentials, treatment plans with calculated doses, drug info from trusted sources and SOAP notes.

Ask WeVet about this

Medically reviewed by

Dr. Ravi Baraiya, B.V.Sc.

Veterinarian · Reviewed 2 Nov 2026

References

TOLFEDINE 4% Injection — Canadian labelDrugs.com Vet — Canadian label text, Vetoquinol · 2026 · Product label
Passage read from this source
Tolfenamic Acid: 40 mg/mL (with 1% W/V of benzyl alcohol as a preservative).
alleviation of inflammation and pain associated with osteoarthritis in dogs with hip dysplasia
administer TOLFEDINE Injection by subcutaneous or intramuscular injection, at a dosage of 4 mg/kg Tolfenamic acid
continue with TOLFEDINE Tablets at the same dosage, for 2 to 4 more days.
Nonsteroidal Anti-inflammatory Drugs in AnimalsMerck Veterinary Manual — S. H. Edwards (updated Sep 2024) · 2024 · Veterinary reference
Passage read from this source
Tolfenamic acid is a fenemate NSAID, and it is a structural analogue of flunixin.
It is approved for use in the EU and other countries.
It is used for fever, postoperative pain, and acute and chronic inflammatory conditions in cats, dogs, cattle, and pigs.
NSAIDs act primarily to reduce the biosynthesis of prostaglandins by inhibiting cyclooxygenase (COX).

For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.