Milbemycin oxime for Animals: Mechanism, Doses by Species & Brands
Milbemycin oxime is a milbemycin, part of the macrocyclic lactone group [2]. With praziquantel (as Milpro) it is given to dogs once by mouth at a minimum of 0.5 mg/kg [1].
- Drug class
- Milbemycin (macrocyclic lactone) antiparasitic
- Sourced doses for
- Dogs
- Brands on this site
- Milpro
Milbemycin oxime dose calculator
Type the strength printed on your own product. Results are calculated in your browser from the cited doses on this page — always check the label of the product you use.
Milbemycin oxime dose by species
| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Intestinal worms (with praziquantel, as Milpro) Minimum dose in the UK Milpro SPC. | 0.5 mg/kg[1] | PO | Single dose | Label |
What milbemycin oxime is used for
- Dogs: roundworms, hookworms, whipworms and (with praziquantel) tapeworms, as a single oral dose (Milpro UK SPC) [1].
How milbemycin oxime works (mechanism of action)
Milbemycin oxime increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels, which leads to paralysis and death of the parasite [1]. Macrocyclic lactones act by binding to glutamate-gated chloride channel receptors in nematode and arthropod nerve cells [2].
Safety, contraindications and precautions
- The margin of safety in certain dogs of Collie or related breeds is less than in other breeds — the recommended dose should be strictly observed [1].
- Treating dogs with a high number of circulating microfilariae can cause hypersensitivity reactions [1].
- Do not use in puppies of less than 2 weeks of age and/or weighing less than 0.5 kg (Milpro UK SPC) [1].
Brands that contain milbemycin oxime
| Brand | Company | Contains | Market |
|---|---|---|---|
| Milpro | Virbac India | Milbemycin oxime + Praziquantel | India |
Frequently asked questions
What is the milbemycin oxime dose for dogs?
The UK Milpro SPC gives a minimum of 0.5 mg/kg milbemycin oxime (with 5 mg/kg praziquantel) once by mouth [1].
Is milbemycin oxime safe in Collies?
The margin of safety in certain dogs of Collie or related breeds is less than in other breeds, so the recommended dose should be strictly observed [1].
References
- Milpro 2.5 mg/25 mg Film-coated Tablets for Small Dogs and Puppies — Summary of Product Characteristics
Passage read from this source
Milbemycin oxime 2.5 mg
0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg are given once orally.
increases nematode and insect membrane permeability to chloride ions via glutamate-gated chloride ion channels
the margin of safety in certain dogs of Collie or related breeds is less than in other breeds
- Pharmacodynamics: Mechanisms of Anthelmintic Action in Animals
Passage read from this source
Macrocyclic lactones act by binding to glutamate-gated chloride channel receptors in nematode and arthropod nerve cells
milbemycins (moxidectin)
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.