Mavacoxib for Animals: Mechanism, Doses by Species & Brands
Mavacoxib is a long-acting coxib-class COX-2 inhibitor approved in the EU and Australia [1]. The first dose is 2 mg/kg by mouth, repeated 14 days later, then once a month — no more than seven doses (6.5 months) in total [1][2].
- Drug class
- Non-steroidal anti-inflammatory drug (NSAID, coxib — long-acting)
- Sourced doses for
- Dogs
- Brands on this site
- Trocoxil
Mavacoxib dose calculator
Type the strength printed on your own product. Results are calculated in your browser from the cited doses on this page — always check the label of the product you use.
Mavacoxib dose by species
| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Osteoarthritis | 2 mg/kg[1] | PO | Day 0 and day 14, then once a month · Not more than 7 doses (6.5 months) | Reference |
What mavacoxib is used for
How mavacoxib works (mechanism of action)
NSAIDs reduce prostaglandin production by inhibiting the cyclooxygenase (COX) enzymes [1]. Mavacoxib is a COX-2 inhibitor whose slow elimination gives it a very long half-life, so it is given at long intervals [1][2].
Safety, contraindications and precautions
Brands that contain mavacoxib
Frequently asked questions
Why is mavacoxib not given every day?
Its slow elimination gives it an extended plasma half-life, so one dose lasts much longer than other NSAIDs [2].
References
- Nonsteroidal Anti-inflammatory Drugs in Animals
Passage read from this source
Mavacoxib is a coxib-class COX-2 inhibitor approved in the EU and Australia
the initial dose is 2 mg/kg, PO, repeated 14 days later
thereafter, the dosing interval is 1 month, with the total course not exceeding seven doses (6.5 months).
NSAIDs act primarily to reduce the biosynthesis of prostaglandins by inhibiting cyclooxygenase (COX).
- Trocoxil (mavacoxib) — data sheet
Passage read from this source
Do not use in dogs less than 12 months of age and/or less than 5 kg bodyweight.
A maximum treatment administration of 6.5 months continuous therapy is recommended
Mavacoxib exhibits an extended plasma half life due to its low rate of elimination.
This corresponds to a duration of effect of 1-2 months after administration of the second dose
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.