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Ketoprofen for Animals: Mechanism, Doses by Species & Brands

Ketoprofen is a propionic acid NSAID [1]. Reference doses are 1 mg/kg a day for up to 5 days in dogs and cats, 2.2 mg/kg a day in horses and 3 mg/kg a day for 1–3 days in cattle [1]. India banned it for animal use in 2023 to protect vultures [3].

Drug class
Non-steroidal anti-inflammatory drug (NSAID, propionic acid derivative)
Sourced doses for
Dogs, Cats, Horses, Cattle
Brands on this site
Ketofen

Ketoprofen dose calculator

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Type the strength printed on your own product. Results are calculated in your browser from the cited doses on this page — always check the label of the product you use.

Ketoprofen dose by species

SpeciesUseDoseRouteHow oftenBasis
DogsPain and inflammation1 mg/kg[1]IV or POOnce daily · Up to 5 daysReference
CatsPain and inflammation1 mg/kg[1]IV or POOnce daily · Up to 5 daysReference
HorsesMusculoskeletal pain and inflammation
Label: 1 mg/lb (1 mL/100 lb) — works out to 2.2 mg/kg (calculated).
2.2 mg/kg[2]IVOnce daily · Up to 5 daysLabel
CattleFever of bovine respiratory disease3 mg/kg[2]SCOnce daily · Up to 3 days if fever persistsLabel

What ketoprofen is used for

  • Horses: inflammation and pain of musculoskeletal disorders (Ketofen US label) [2].
  • Cattle: fever of bovine respiratory disease in certain classes of cattle (Ketofen US label) [2].
  • Dogs and cats: reference dose in the Merck Veterinary Manual [1].

How ketoprofen works (mechanism of action)

NSAIDs reduce prostaglandin production by inhibiting the cyclooxygenase (COX) enzymes [1].

Safety, contraindications and precautions

  • India: in July 2023 veterinary ketoprofen (and aceclofenac) could no longer be manufactured, sold or distributed, to protect vultures [3].
  • Ketofen (US) must not be used in horses intended for human consumption, or in female dairy cattle 1 year of age or older [2].

Withdrawal periods

Withdrawal periods belong to a product and a country — the rows below name the product they come from. Always follow the label of the product you use.

SpeciesProductWithdrawalDetail
CattleMeat2 daysKetofen (US): not slaughtered within 48 hours of the last treatment.[2]

Brands that contain ketoprofen

BrandCompanyContainsMarket
KetofenZoetisKetoprofenUSA (FDA label)

Frequently asked questions

Is ketoprofen banned in India?

Yes as a veterinary drug — in July 2023 India stopped its manufacture, sale and distribution, to protect vultures [3].

What is the ketoprofen dose for horses?

Under the US Ketofen label, 1 mg/lb (about 2.2 mg/kg) IV once a day for up to 5 days [2].

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R
Medically reviewed by
Dr. Ravi Baraiya, B.V.Sc.
Veterinarian · Reviewed 2 Nov 2026

References

  1. Nonsteroidal Anti-inflammatory Drugs in AnimalsMerck Veterinary Manual — S. H. Edwards (updated Sep 2024) · 2024 · Veterinary reference
    Passage read from this source
    Ketoprofen is another propionic acid derivative
    The recommended dosage is 1 mg/kg per day for up to 5 days, IV or PO in dogs and cats
    2.2 mg/kg per day for up to 5 days, IV, in horses
    3 mg/kg per day for 1–3 days, IV or IM, in cattle
  2. KETOFEN (ketoprofen) injection — labelDrugs.com Vet — US label text, Zoetis · 2026 · Product label
    Passage read from this source
    The recommended dosage is 1 mg/lb (1 mL/100 lbs) of body weight
    Treatment may be repeated for up to five days.
    Do not use in horses intended for human consumption.
    The recommended dosage is 3 mg/kg (1 mL/33.3 kg) or 1.36 mg/lb (1 mL/74 lb) of body weight.
  3. Bans on two more veterinary drugs linked to vulture deaths in IndiaBirdLife International (news, Sep 2023) · 2023 · Journal article
    Passage read from this source
    On the 31st of July, Bombay Natural History Society (BNHS), BirdLife in India,
    received the good news that two more veterinary drugs- Ketoprofen and Aceclofenac,
    could no longer be manufactured, sold and distributed throughout India.
    to remove Diclofenac from veterinary practice in India in 2006.

For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.

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