Praziquantel for Animals: Mechanism, Doses by Species & Brands
Praziquantel is an anthelmintic against tapeworms whose action is related to calcium-channel disruption, causing paralysis and death of the tapeworm [2]. With milbemycin oxime (as Milpro) it is given to dogs once by mouth at a minimum of 5 mg/kg [1].
- Drug class
- Isoquinoline anthelmintic (tapeworms)
- Sourced doses for
- Dogs
- Brands on this site
- Milpro
Praziquantel dose calculator
Type the strength printed on your own product. Results are calculated in your browser from the cited doses on this page — always check the label of the product you use.
Praziquantel dose by species
| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Tapeworms (with milbemycin oxime, as Milpro) Minimum dose in the UK Milpro SPC. | 5 mg/kg[1] | PO | Single dose | Label |
What praziquantel is used for
- Dogs: tapeworms, combined with milbemycin oxime in Milpro [1].
How praziquantel works (mechanism of action)
Praziquantel modifies the permeability of the parasite membranes for calcium (influx of Ca2+), causing contraction of the parasite musculature [1][2]. Paralysis results, leading to tapeworm death [2].
Safety, contraindications and precautions
- Do not use in cases of hypersensitivity to the active substances or to any of the excipients (Milpro UK SPC) [1].
Brands that contain praziquantel
| Brand | Company | Contains | Market |
|---|---|---|---|
| Milpro | Virbac India | Milbemycin oxime + Praziquantel | India |
Frequently asked questions
What is the praziquantel dose for dogs?
The UK Milpro SPC gives a minimum of 5 mg/kg praziquantel (with 0.5 mg/kg milbemycin oxime) once by mouth [1].
References
- Milpro 2.5 mg/25 mg Film-coated Tablets for Small Dogs and Puppies — Summary of Product Characteristics
Passage read from this source
Praziquantel 25 mg
0.5 mg of milbemycin oxime and 5 mg of praziquantel per kg are given once orally.
It modifies the permeability for calcium (influx of Ca2+) in the membranes of the parasite.
Do not use in cases of hypersensitivity to the active substances or to any of the excipients.
- Pharmacodynamics: Mechanisms of Anthelmintic Action in Animals
Passage read from this source
The mechanism of action is related to calcium-channel disruption.
Paralysis results, leading to tapeworm death.
The primary effect of praziquantel is the contraction of parasite musculature
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.