Grapiprant for Animals: Mechanism, Doses by Species & Brands
Grapiprant is a PGE2 antagonist that acts at the EP4 receptor and is not a COX-1 or COX-2 inhibitor [1]. Under the Galliprant label dogs get 2 mg/kg by mouth once a day for osteoarthritis pain and inflammation [2].
- Drug class
- Piprant — prostaglandin E2 EP4 receptor antagonist (not a COX inhibitor)
- Sourced doses for
- Dogs
- Brands on this site
- Galliprant, Grapitail
Grapiprant dose calculator
Type the strength printed on your own product. Results are calculated in your browser from the cited doses on this page — always check the label of the product you use.
Grapiprant dose by species
| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Osteoarthritis pain and inflammation Label: 0.9 mg/lb (2 mg/kg). | 2 mg/kg[2] | PO | Once daily | Label |
What grapiprant is used for
- Dogs: control of pain and inflammation associated with osteoarthritis (Galliprant label) [2].
How grapiprant works (mechanism of action)
Grapiprant blocks the EP4 receptor, one of the receptors through which prostaglandin E2 causes pain and inflammation [1][2]. Because it does not inhibit the COX enzymes it works differently from classic NSAIDs [1].
Safety, contraindications and precautions
Brands that contain grapiprant
| Brand | Company | Contains | Market |
|---|---|---|---|
| Galliprant | Elanco | Grapiprant | USA (FDA label) |
| Grapitail | Vivaldis Health and Foods | Grapiprant | India |
Frequently asked questions
Is grapiprant an NSAID?
It is grouped with anti-inflammatories but works differently: it blocks the EP4 prostaglandin receptor and does not inhibit COX-1 or COX-2 [1].
What is the grapiprant dose for dogs?
2 mg/kg by mouth once a day (Galliprant label) [2].
References
- Nonsteroidal Anti-inflammatory Drugs in Animals
Passage read from this source
Grapiprant is a novel PGE2 antagonist, acting at the EP4 receptor.
It is not a COX-1 or COX-2 inhibitor.
- GALLIPRANT (grapiprant tablets) — label
Passage read from this source
The dose of GALLIPRANT (grapiprant tablets) is 0.9 mg/lb (2 mg/kg) once daily.
Dogs less than 8 lbs. (3.6 kgs) cannot be accurately dosed.
The safe use of GALLIPRANT has not been evaluated in dogs younger than 9 months of age and less than 8 lbs (3.6 kgs),
Do not administer GALLIPRANT in conjunction with any other oral or injectable NSAID or corticosteroid.
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.