Drug guide
Grapiprant for Dogs: Dosage, Contraindications & Safety
GALLIPRANT is grapiprant tablets, and GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2). [1] In client-owned dogs, GALLIPRANT was evaluated at doses of 2 mg/kg once daily, 5 mg/kg once daily, 4 mg/kg twice daily, or placebo twice daily. [1] In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]
What grapiprant is
- GALLIPRANT is grapiprant tablets, and GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2). [1]
Grapiprant dose for dogs
| Species | Dose | Route | Frequency / duration | Product / notes |
|---|---|---|---|---|
| Dog | 0.9 mg/lb (2 mg/kg) | Once daily for 28 days | GALLIPRANT was given in a controlled field study [1] |
- In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]
- In client-owned dogs, GALLIPRANT was evaluated at doses of 2 mg/kg once daily, 5 mg/kg once daily, 4 mg/kg twice daily, or placebo twice daily. [1]
Dogs that should not receive grapiprant
- If additional pain medication is needed after a daily dose of GALLIPRANT, a non-NSAID/non-corticosteroid class of analgesic may be necessary. [1]
- In a controlled field study, GALLIPRANT-treated dogs ranged in age from 2 to 16.75 years. [1]
- Patients at greatest risk for adverse events with NSAIDs are those that are dehydrated, on concomitant diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction. [1]
- Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. [1]
- Dogs that are dehydrated or on concomitant diuretic therapy are among those at greatest risk for adverse events [1].
Grapiprant and other drugs
- The influence of concomitant drugs that may inhibit metabolism of GALLIPRANT has not been evaluated. [1]
- Concurrent administration of potentially nephrotoxic drugs with GALLIPRANT should be carefully approached and monitored. [1]
- Concurrent use of potentially nephrotoxic drugs should be carefully approached and monitored [1].
Adverse effects reported with grapiprant
- In a controlled field study, 285 dogs were evaluated for safety on GALLIPRANT or a vehicle control [1].
- The most common treatment-related adverse reactions were diarrhea, vomiting and inappetence [1].
- In a field study conducted in 366 client-owned dogs, the most common adverse reactions related to GALLIPRANT treatment were diarrhea, vomiting and inappetence. [1]
Laboratory changes at higher doses
- In the label's safety study, serum albumin and total protein decreased with increasing doses of grapiprant [1].
Frequently asked questions
What is the grapiprant dose for dogs?
In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]
Can grapiprant be combined with other NSAIDs or steroids?
If additional pain medication is needed after a daily dose of GALLIPRANT, a non-NSAID/non-corticosteroid class of analgesic may be necessary. [1]
What is the minimum age for grapiprant in dogs?
In a controlled field study, GALLIPRANT-treated dogs ranged in age from 2 to 16.75 years. [1]
What are the most common side effects of grapiprant?
Diarrhea, vomiting and inappetence were the most common treatment-related adverse reactions [1].
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- Galliprant (grapiprant tablets) — Product Information
Passage read from this source
As a class, NSAIDs may be associated with gastrointestinal, renal, and hepatic toxicity. Sensitivity to drug-associated adverse events varies with the individual patient. Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. Patients at greatest risk for adverse events are those that are dehydrated, on concomitant diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction.
If additional pain medication is needed after a daily dose of GALLIPRANT, a non-NSAID/non-corticosteroid class of analgesic may be necessary. Concurrent administration of potentially nephrotoxic drugs should be carefully approached and monitored. NSAIDs may inhibit the prostaglandins that maintain normal homeostatic function. GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2).
The concomitant use of protein-bound drugs with GALLIPRANT has not been studied in dogs. Commonly used protein-bound drugs include cardiac, anticonvulsant and behavioral medications. The influence of concomitant drugs that may inhibit metabolism of GALLIPRANT has not been evaluated. Drug compatibility should be monitored in patients requiring adjunctive therapy.
In a controlled field study, 285 dogs were evaluated for safety when given either GALLIPRANT or a vehicle control (tablet minus grapiprant) at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. GALLIPRANT-treated dogs ranged in age from 2 to 16.75 years. The following adverse reactions were observed:
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