Gardplus (Cefoperazone + Sulbactam) Dose for Cattle: Strengths & Dose Calculator
Gardplus is a cefoperazone + sulbactam injection from Virbac India; each 4500 mg vial contains cefoperazone sodium 3000 mg and sulbactam sodium 1500 mg, with 20 mL of sterile water for injection in the pack [1]. The dose is 5–10 mg cefoperazone per kg body weight by IM or IV route [1].
- Contains
- Cefoperazone + Sulbactam
- Company
- Virbac India
- Forms
- Gardplus 4500 mg vial
- Label species
- Cattle
- Data from
- India
- Type
- Antibiotic
Gardplus dose calculator
Results are calculated in your browser from the doses and strengths on this page. Check the strength printed on your pack and the label in your country before giving any dose.
Gardplus strengths and presentations
Gardplus dose by species
| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Cattle | Bacterial infections (Gram-positive and Gram-negative) Dose is mg of cefoperazone per kg. | 5–10 mg/kg[1] | IM or IV | Not stated on the page | Label |
Label directions
Warnings and precautions
- Hypersensitivity reactions have occurred with cephalosporins, with cross-reactivity to penicillin allergies possible [2].
About cefoperazone (the active ingredient)
Third-generation cephalosporin (beta-lactam) antibacterial.
How it works
As a beta-lactam, it inhibits the penicillin-binding proteins and so bacterial cell wall synthesis [4]. Biliary elimination of newer cephalosporins such as cefoperazone may be appreciable [2].
Key safety points
About sulbactam (the active ingredient)
Beta-lactamase inhibitor.
How it works
Inhibitors of beta-lactamases (e.g. clavulanic acid and sulbactam) were added to minimise destruction of the partner beta-lactam drug by bacterial enzymes [4].
Pack sizes
- 4500 mg glass vial with 20 mL sterile water for injection [1].
Frequently asked questions
What is in Gardplus injection?
Each 4500 mg vial contains cefoperazone sodium 3000 mg and sulbactam sodium 1500 mg [1].
What is the Gardplus dose for cattle?
5–10 mg of cefoperazone per kg body weight by IM or IV route [1].
More from Virbac India
Gardplus is a trademark of its owner. This page is an independent clinical reference and is not affiliated with Virbac India. Strengths, species and withdrawal periods can differ between countries — always follow the pack insert in your country.
References
- GARDPLUS® Injection
Passage read from this source
Each 4500 mg vial contains:
Cefoperazone Sodium 3000 mg
Sulbactam Sodium 1500 mg
This pack also contain: one unit of Sterile water for injections IP 20 ml
- Cephalosporins and Cephamycins Use in Animals
Passage read from this source
Hypersensitivity reactions of several forms have occurred, with cross-reactivity to penicillin allergies possible.
Biliary elimination of the newer cephalosporins (eg, cefoperazone) may be appreciable.
Cephalosporins injections IM can be painful, and repeated IV administration may lead to local phlebitis.
- Cefoperazone — Summary report (Committee for Veterinary Medicinal Products)
Passage read from this source
Cefoperazone is a third generation semi-synthetic cephalosporin with a broad spectrum of activity
Cefoperazone sodium and -dihydrate are used for intramammary treatment of clinical mastitis in lactating cattle.
Dose levels used are 250 mg cefoperazone sodium per infected quarter once
100 mg cefoperazone dihydrate per infected quarter twice with a dosing interval of 24 hours.
- Beta-lactam Antimicrobial Use in Animals
Passage read from this source
The beta-lactam drug mimics the PBP substrate, thus inhibiting the PBP and subsequent cell wall synthesis.
Inhibitors of beta-lactamases (eg, clavulanic acid and sulbactam) were added to minimize penicillin destruction.
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.