Active ingredient
Cefoperazone for Animals: Mechanism, Doses by Species & Brands
Cefoperazone is a third-generation semi-synthetic cephalosporin with a broad spectrum of activity [1][2]. In the EU it is used for intramammary treatment of clinical mastitis in lactating cattle [1].
- Drug class
- Third-generation cephalosporin (beta-lactam) antibacterial
- Brands on this site
- Gardplus
What cefoperazone is used for
- Intramammary treatment of clinical mastitis in lactating cattle — 250 mg cefoperazone sodium per infected quarter once, or 100 mg cefoperazone dihydrate per quarter twice 24 hours apart (EU) [1].
How cefoperazone works (mechanism of action)
As a beta-lactam, it inhibits the penicillin-binding proteins and so bacterial cell wall synthesis [3]. Biliary elimination of newer cephalosporins such as cefoperazone may be appreciable [2].
Safety, contraindications and precautions
Brands that contain cefoperazone
| Brand | Company | Contains | Market |
|---|---|---|---|
| Gardplus | Virbac India | Cefoperazone + Sulbactam | India |
Frequently asked questions
Have a case in front of you?Ask WeVet — the AI assistant built for veterinarians. Differentials, treatment plans with calculated doses, drug info from trusted sources and SOAP notes.
Ask WeVet about thisMedically reviewed by
Dr. Ravi Baraiya, B.V.Sc.
Veterinarian · Reviewed 2 Nov 2026
References
- Cefoperazone — Summary report (Committee for Veterinary Medicinal Products)
Passage read from this source
Cefoperazone is a third generation semi-synthetic cephalosporin with a broad spectrum of activity
Cefoperazone sodium and -dihydrate are used for intramammary treatment of clinical mastitis in lactating cattle.
Dose levels used are 250 mg cefoperazone sodium per infected quarter once
100 mg cefoperazone dihydrate per infected quarter twice with a dosing interval of 24 hours.
- Cephalosporins and Cephamycins Use in Animals
Passage read from this source
Biliary elimination of the newer cephalosporins (eg, cefoperazone) may be appreciable.
Hypersensitivity reactions of several forms have occurred, with cross-reactivity to penicillin allergies possible.
Cephalosporins injections IM can be painful, and repeated IV administration may lead to local phlebitis.
- Beta-lactam Antimicrobial Use in Animals
Passage read from this source
The beta-lactam drug mimics the PBP substrate, thus inhibiting the PBP and subsequent cell wall synthesis.
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.