# Solu-Delta-Cortef (Prednisolone) Dose for Dogs & Cats: Strengths & Dose Calculator

> Solu-Delta-Cortef is prednisolone sodium succinate powder for injection (100 mg or 500 mg per vial) from Zoetis, for shock, adrenal failure, acute arthritis, laminitis and acute hypersensitivity reactions. Dogs in shock get…

- Source page: https://wevet.in/vet-products/solu-delta-cortef-prednisolone/
- Type: Vet product
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Solu-Delta-Cortef is prednisolone sodium succinate powder for injection (100 mg or 500 mg per vial) from Zoetis, for shock, adrenal failure, acute arthritis, laminitis and acute hypersensitivity reactions [1]. Dogs in shock get 2.5–5 mg/lb IV as a first dose; horses 50–100 mg [1].

- Brand: Solu-Delta-Cortef
- Contains: Prednisolone
- Company: Zoetis
- Label species: Dogs, Cats, Horses
- Data from: USA (FDA label)

## Strengths

- Solu-Delta-Cortef 100 mg vial (10 mg/mL mixed): Prednisolone 10 mg per mL (verified, [1])
- Solu-Delta-Cortef 500 mg vial (50 mg/mL mixed): Prednisolone 50 mg per mL (verified, [1])

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Shock — first dose (Label: 2.5–5 mg/lb — works out to 5.5–11 mg/kg (calculated).) | 5.5–11 mg/kg [1] | IV | Then equal doses at 1-, 3-, 6- or 10-hour intervals | Label |
| Horses | First dose | 50–100 mg/animal [1] | IV or IM | Repeat at 12, 24 or 48 hours | Label |
| Cats | Anti-inflammatory / anti-allergic | 0.1–2 mg/kg [3] | PO | Once daily (evening) · Often 1–3 weeks, then alternate days | Reference — prednisolone |
| Cats | Allergic itch (anti-inflammatory dose) | 0.5–1 mg/kg [2] | PO | Daily | Reference — prednisolone |

## Label directions

- Dogs, shock: 2.5–5 mg/lb IV, then equal doses at 1-, 3-, 6- or 10-hour intervals [1].
- Dogs and cats IM: usually 1–5 mg, up to 30–50 mg in large dogs; may repeat in 12–24 hours for 3–5 days [1].
- Horses: 50–100 mg as a first dose [1].

## Warnings and precautions

- Contraindicated with tuberculosis, Cushing’s syndrome and peptic ulcer; do not use in viral infections [1].
- Do not give the 50 mg/mL solution IM to dogs and cats [1].
- May induce parturition in the last trimester of pregnancy [1].


Interactive dose calculator (strength prefilled only when confirmed): use the page link above.

## Frequently asked questions

### What is the Solu-Delta-Cortef dose for a dog in shock?

2.5–5 mg per lb IV as the first dose, then equal maintenance doses [1].

## References

[1] SOLU-DELTA-CORTEF (prednisolone sodium succinate) — label — Drugs.com Vet — US label text, Zoetis (2026). https://www.drugs.com/vet/solu-delta-cortef.html
[2] Corticosteroids in Animals — Merck Veterinary Manual (2024). https://www.merckvetmanual.com/pharmacology/inflammation/corticosteroids-in-animals
[3] Prednicare 5 mg tablets — SPC — UK Veterinary Medicines Directorate — Ecuphar SPC (2026). https://www.vmd.defra.gov.uk/ProductInformationDatabase/files/SPC_Documents/SPC_113952.PDF
[4] Prednidale 25 mg tablets for dogs — SPC — UK Veterinary Medicines Directorate — Dechra SPC (2026). https://www.vmd.defra.gov.uk/ProductInformationDatabase/files/SPC_Documents/SPC_2974718.PDF

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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