# Predef 2X (Isoflupredone acetate) Dose for Cattle & Horses: Strengths & Dose Calculator

> Predef 2X is isoflupredone acetate 2 mg/mL from Zoetis, used for primary bovine ketosis and inflammatory conditions in cattle, horses and pigs. Cattle get 10–20 mg IM, horses 5–20 mg and pigs…

- Source page: https://wevet.in/vet-products/predef-2x-isoflupredone-acetate/
- Type: Vet product
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Predef 2X is isoflupredone acetate 2 mg/mL from Zoetis, used for primary bovine ketosis and inflammatory conditions in cattle, horses and pigs [1]. Cattle get 10–20 mg IM, horses 5–20 mg and pigs 5 mg for a 300 lb animal [1].

- Brand: Predef 2X
- Contains: Isoflupredone acetate
- Company: Zoetis
- Label species: Cattle, Horses, Pigs
- Data from: USA (FDA label)

## Strengths

- Predef 2X injection 2 mg/mL: Isoflupredone acetate 2 mg per mL (verified, [1])

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Cattle | Ketosis and inflammatory conditions | 10–20 mg/animal [1] | IM | May be repeated in 12–24 hours | Label |
| Horses | Inflammatory conditions | 5–20 mg/animal [1] | IM | Repeated as necessary | Label |
| Pigs | Inflammatory conditions (5 mg for a 300 lb pig.) | 5 mg/animal [1] | IM |  | Label |

## Label directions

- Cattle: 10–20 mg IM by size and severity; may repeat in 12–24 hours [1].
- Horses: 5–20 mg IM, repeated as necessary [1].
- Pigs: 5 mg IM for a 300 lb animal [1].

## Warnings and precautions

- Stop if signs of low potassium (hypokalaemia) appear [1].
- May induce parturition in the last trimester of pregnancy [1].
- Do not use in veal calves or in horses intended for human consumption [1].

## Withdrawal periods

- Cattle, meat: 7 days — Not slaughtered within 7 days of the last treatment. [1]
- Pigs, meat: 7 days — Not slaughtered within 7 days of the last treatment. [1]

Interactive dose calculator (strength prefilled only when confirmed): use the page link above.

## Frequently asked questions

### What is the Predef 2X dose for cows with ketosis?

10–20 mg IM (5–10 mL), repeatable in 12–24 hours [1].

### What is the meat withdrawal for Predef 2X?

7 days [1].

## References

[1] PREDEF 2X (isoflupredone acetate) — label — Drugs.com Vet — US label text, Zoetis (2026). https://drugs.com/vet/predef-2x.html
[2] Corticosteroids in Animals — Merck Veterinary Manual (2024). https://www.merckvetmanual.com/pharmacology/inflammation/corticosteroids-in-animals

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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