# Heartgard Plus (Ivermectin + Pyrantel (pamoate)) Dose for Dogs: Strengths & Dose Calculator

> Heartgard Plus chewables combine ivermectin and pyrantel to prevent heartworm and treat roundworms and hookworms in dogs from 6 weeks of age, given once a month at a minimum of 6 mcg/kg…

- Source page: https://wevet.in/vet-products/heartgard-plus-ivermectin-pyrantel-pamoate/
- Type: Vet product
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Heartgard Plus chewables combine ivermectin and pyrantel to prevent heartworm and treat roundworms and hookworms in dogs from 6 weeks of age, given once a month at a minimum of 6 mcg/kg ivermectin and 5 mg/kg pyrantel [1]. The chewable is chosen by body-weight band [1].

- Brand: Heartgard Plus
- Contains: Ivermectin + Pyrantel (pamoate)
- Company: Boehringer Ingelheim Animal Health
- Label species: Dogs
- Data from: USA (FDA label)

## Strengths

- Heartgard Plus chewables: Ivermectin strength not confirmed (verified, [1]); Pyrantel (pamoate) strength not confirmed (verified, [1])
  - 0–25 lb: Blue — 68 mcg ivermectin / 57 mg pyrantel
  - 26–50 lb: Green — 136 mcg / 114 mg
  - 51–100 lb: Brown — 272 mcg / 227 mg

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Heartworm prevention; roundworms and hookworms (Minimum dose; pyrantel 5 mg/kg.) | 6 mcg/kg [1] | PO | Once a month | Label |
| Dogs | Roundworms and hookworms (as Heartgard Plus) (Minimum dose; as pamoate salt.) | 5 mg/kg [1] | PO | Once a month | Label |

## Label directions

- Give orally once a month at a minimum of 6 mcg/kg ivermectin and 5 mg/kg pyrantel, using the chewable for the dog's weight band [1].
- Test dogs for heartworm infection before starting; infected dogs must be treated to remove adult heartworms and microfilariae first [1].

## Warnings and precautions

- For dogs 6 weeks of age and older [1].
- Choking or intestinal obstruction has been reported after dosing [1].


Interactive dose calculator (strength prefilled only when confirmed): use the page link above.

## Frequently asked questions

### Which Heartgard Plus is for my dog's weight?

Up to 25 lb: 68 mcg/57 mg (blue); 26–50 lb: 136 mcg/114 mg (green); 51–100 lb: 272 mcg/227 mg (brown); over 100 lb: a combination of chewables [1].

### Is Heartgard Plus safe for Collies?

At the label dose, yes: Heartgard showed no toxicity at 10 times the dose (60 mcg/kg) in ivermectin-sensitive Collies [1].

## References

[1] HEARTGARD PLUS (ivermectin and pyrantel pamoate) chewable — label — DailyMed (US NLM) — FDA-approved label, Boehringer Ingelheim (2026). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=595a4883-6b37-4190-9579-a2c7ca4738eb
[2] Mange in Dogs and Cats — Merck Veterinary Manual — M. W. Dryden (reviewed 2023, updated May 2025) (2025). https://www.merckvetmanual.com/integumentary-system/mange/mange-in-dogs-and-cats
[3] Pharmacodynamics: Mechanisms of Anthelmintic Action in Animals — Merck Veterinary Manual — E. Claerebout & C. E. Lanusse (Apr 2025) (2025). https://www.merckvetmanual.com/pharmacology/anthelmintics/pharmacodynamics-mechanisms-of-anthelmintic-action-in-animals
[4] IVOMEC (ivermectin) injection, solution — label — DailyMed (US NLM) — FDA-approved label, Boehringer Ingelheim (2026). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=84fe39b2-0423-479a-b81f-198e2fb4e826

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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