# Furosemide and Gentamicin Interaction in Dogs: Risks & Management

> In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity. The concurrent use of gentamicin with potent diuretics,…

- Source page: https://wevet.in/interactions/furosemide-and-gentamicin-interaction/
- Type: Drug interaction
- Publisher: WeVet
- Updated: 2026-11-01
- Audience: veterinarians and veterinary students

In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]

## The interaction
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]
- In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]
- The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]
- The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]

## Interaction table
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]

| Drugs | Severity (as the source states it) | Effect | Management |
|---|---|---|---|
| Gentamicin + furosemide | Should be avoided. [2][3] | In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity. [5] Concurrent use with potent diuretics such as furosemide may cause ototoxicity, and when administered intravenously, diuretics may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue. [2][3] | Avoid concurrent use of gentamicin with potent diuretics such as furosemide. [2][3] |

## Mechanism
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]

## Monitoring & management
The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]
- The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]
- In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]
- In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]

## Species notes
In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]
- In dogs, concurrent administration of furosemide with aminoglycosides may enhance nephrotoxicity.[5]
- The concurrent use of gentamicin with potent diuretics, such as furosemide, should be avoided, and when diuretics are administered intravenously they may enhance aminoglycoside toxicity by altering the antibiotic concentration in serum and tissue.[2][3]

## References

[1] Revised: April 2025 AN: 00774/2024 & 00775/2024 Page 1 of 8 — www.vmd.defra.gov.uk (Mar 8, 2021). https://www.vmd.defra.gov.uk/productinformationdatabase/files/SPC_Documents/SPC_2048181.PDF
[2] Gentamicin injection - accessdata.fda.gov — www.accessdata.fda.gov. https://www.accessdata.fda.gov/drugsatfda_docs/label/2014/062366s033lbl.pdf
[3] Gentamicin Sulfate Injection, USP 80mg/2ml (40 mg/mL as ... — dailymed.nlm.nih.gov. https://dailymed.nlm.nih.gov/dailymed/fda/fdaDrugXsl.cfm?setid=913a36c3-50d6-429a-a8dd-a03126d2ca08&type=display
[4] Gentamicin - Veterinary Medicines Directorate — www.vmd.defra.gov.uk. https://www.vmd.defra.gov.uk/productinformationdatabase/files/SPC_Documents/SPC_1476978.PDF
[5] AmiJect D for Dogs — www.drugs.com (May 28, 2026). https://www.drugs.com/vet/amiject-d.html
[6] Fatal nephrotoxicosis associated with furosemide and ... - PubMed — pubmed.ncbi.nlm.nih.gov (Oct 15, 1983). https://pubmed.ncbi.nlm.nih.gov/6630000/

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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