Drug interaction
Enrofloxacin and Sucralfate Interaction in Dogs: Risks & Management
In dogs, enrofloxacin given with sucralfate may reduce absorption of enrofloxacin because sucralfate is listed among magnesium or aluminium containing substances associated with this effect.[2][5] Dog enrofloxacin tablet labels state that enrofloxacin and sucralfate should be administered two hours apart.[2][5]
The interaction
The key interaction is reduced absorption of enrofloxacin when enrofloxacin is used concurrently with sucralfate in dogs.[2][5]
- Effect: In dogs, concurrent use of sucralfate may reduce absorption of enrofloxacin.[2][5]
- Management: In dogs, enrofloxacin and sucralfate should be administered two hours apart.[2][5]
Interaction table
| Drugs | Severity (as the source states it) | Effect | Management |
|---|---|---|---|
| Enrofloxacin + sucralfate in dogs | Not stated.[2] | Concurrent use of sucralfate may reduce absorption of enrofloxacin.[2] | Enrofloxacin and sucralfate should be administered two hours apart.[2] |
| Enrofloxacin + sucralfate in cats and dogs | Not stated.[5] | Concurrent use of sucralfate may reduce absorption of enrofloxacin.[5] | Enrofloxacin and sucralfate should be administered two hours apart.[5] |
Mechanism
The mechanism stated by dog and cats-and-dogs enrofloxacin tablet labels is that magnesium or aluminium containing substances such as sucralfate may reduce absorption of enrofloxacin.[2][5]
Monitoring & management
The main management point is to separate dosing of enrofloxacin and sucralfate by two hours.[2][5]
- Dose separation: Dog enrofloxacin tablet labels state that enrofloxacin and sucralfate should be administered two hours apart.[2][5]
Species notes
This interaction is stated on an enrofloxacin tablet label for dogs.[2]
A cats-and-dogs enrofloxacin tablet label gives the same interaction and the same instruction to administer the drugs two hours apart.[5]
Frequently asked questions
Does sucralfate reduce enrofloxacin absorption in dogs?
A dog enrofloxacin tablet label states that concurrent use of magnesium or aluminium containing substances such as sucralfate may reduce absorption of enrofloxacin.[2]
How far apart should enrofloxacin and sucralfate be given in dogs?
What is the stated effect of giving enrofloxacin with sucralfate in dogs?
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Dr. Ankush Mayani, M.V.Sc.
Veterinarian · Reviewed 27 Oct 2026
References
- A. LABELLING - Veterinary Medicines Directorate
Passage read from this source
Pregnancy and lactation: Studies in laboratory animals (rat, chinchilla) have not produced any evidence of a teratogenic, foetotoxic, maternotoxic effect. Use only according to the benefit/risk assessment by the responsible veterinarian. As enrofloxacin passes into the maternal milk, the use is not recommended during lactation. Interaction with other medicinal products and other forms of interaction: Concurrent use of flunixin should be under careful veterinary monitoring, as the interactions between these drugs may lead to adverse events related to delayed elimination. Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase. Concurrent use of magnesium or aluminium containing substances (such as antacids or sucralfate) may reduce absorption of enrofloxacin. These drugs should be administered two hours apart.
- Floxabactin 150 mg tablets for dogs
Passage read from this source
Revised: May 2021 AN: 00832/2020 Page 3 of 6 Use during lactation: As enrofloxacin passes into the maternal milk, the use is not recommended during lactation. 4.8 Interaction with other medicinal products and other forms of interaction Concurrent use of flunixin should be under careful veterinary monitoring, as the interactions between these drugs may lead to adverse events related to delayed elimination. Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase. Concurrent use of magnesium or aluminium containing substances (such as antacids or sucralfate) may reduce absorption of enrofloxacin. These drugs should be administered two hours apart. Do not administer simultaneously with tetracyclines, phenicols or macrolides because of potential antagonistic effects.
- Zobuxa 150 mg tablets for dogs
Passage read from this source
Revised: October 2017 AN: 01305/2017 Page 3 of 6 4.7 Use during pregnancy, lactation or lay Pregnancy and lactation: Studies in laboratory animals (rat, chinchilla) have not produced any evidence of a teratogenic, foetotoxic, maternotoxic effect. Use only according to the benefit/risk assessment by the responsible veterinarian. As enrofloxacin passes into the maternal milk, the use is not recommended during lactation. 4.8 Interaction with other medicinal products and other forms of interaction Concurrent use of flunixin should be under careful veterinary monitoring, as the interactions between these drugs may lead to adverse events related to delayed elimination. Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase.
- Zobuxa 50 mg tablets for cats and dogs
Passage read from this source
Revised: October 2017 AN: 01305/2017 Page 3 of 6 4.7 Use during pregnancy, lactation or lay Pregnancy and lactation: Studies in laboratory animals (rat, chinchilla) have not produced any evidence of a teratogenic, foetotoxic, maternotoxic effect. Use only according to the benefit/risk assessment by the responsible veterinarian. As enrofloxacin passes into the maternal milk, the use is not recommended during lactation. 4.8 Interaction with other medicinal products and other forms of interaction Concurrent use of flunixin should be under careful veterinary monitoring, as the interactions between these drugs may lead to adverse events related to delayed elimination. Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase.
- Floxabactin 15 mg tablets for cats and dogs
Passage read from this source
Revised: April 2025 AN: 02325/2023 and 02328/2023 Page 4 of 7 Concomitant administration of theophylline requires careful monitoring as serum levels of theophylline may increase. Concurrent use of magnesium or aluminium containing substances (such as antacids or sucralfate) may reduce absorption of enrofloxacin. These drugs should be administered two hours apart. Do not administer simultaneously with tetracyclines, phenicols or macrolides because of potential antagonistic effects. Do not administer simultaneously with non-steroidal anti-inflammatory drugs, convulsions can occur. 3.9 Administration routes and dosage Oral use.
- Revised: December 2025 MA split from NI Expiry following AN
Passage read from this source
Concurrent use of magnesium or aluminum containing substances (such as antacids or sucralfate) may reduce absorption of enrofloxacin.
For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.