# Grapiprant for Dogs: Dosage, Contraindications & Safety

> GALLIPRANT is grapiprant tablets, and GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2). In client-owned dogs, GALLIPRANT was evaluated…

- Source page: https://wevet.in/drugs/grapiprant-dogs/
- Type: Drug guide
- Publisher: WeVet
- Updated: 2026-10-28
- Audience: veterinarians and veterinary students

GALLIPRANT is grapiprant tablets, and GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2). [1] In client-owned dogs, GALLIPRANT was evaluated at doses of 2 mg/kg once daily, 5 mg/kg once daily, 4 mg/kg twice daily, or placebo twice daily. [1] In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]

## What grapiprant is
- GALLIPRANT is grapiprant tablets, and GALLIPRANT blocks the activity of the specific prostaglandin E2 (PGE2). [1]

## Grapiprant dose for dogs
| Species | Dose | Route | Frequency / duration | Product / notes |
|---|---|---|---|---|
| Dog | 0.9 mg/lb (2 mg/kg) |  | Once daily for 28 days | GALLIPRANT was given in a controlled field study [1] |

- In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]
- In client-owned dogs, GALLIPRANT was evaluated at doses of 2 mg/kg once daily, 5 mg/kg once daily, 4 mg/kg twice daily, or placebo twice daily. [1]

## Dogs that should not receive grapiprant
- If additional pain medication is needed after a daily dose of GALLIPRANT, a non-NSAID/non-corticosteroid class of analgesic may be necessary. [1]
- In a controlled field study, GALLIPRANT-treated dogs ranged in age from 2 to 16.75 years. [1]
- Patients at greatest risk for adverse events with NSAIDs are those that are dehydrated, on concomitant diuretic therapy, or those with existing renal, cardiovascular, and/or hepatic dysfunction. [1]
- Dogs that have experienced adverse reactions from one NSAID may experience adverse reactions from another NSAID. [1]
- Dogs that are dehydrated or on concomitant diuretic therapy are among those at greatest risk for adverse events [1].

## Grapiprant and other drugs
- The influence of concomitant drugs that may inhibit metabolism of GALLIPRANT has not been evaluated. [1]
- Concurrent administration of potentially nephrotoxic drugs with GALLIPRANT should be carefully approached and monitored. [1]
- Concurrent use of potentially nephrotoxic drugs should be carefully approached and monitored [1].

## Adverse effects reported with grapiprant
- In a controlled field study, 285 dogs were evaluated for safety on GALLIPRANT or a vehicle control [1].
- The most common treatment-related adverse reactions were diarrhea, vomiting and inappetence [1].
- In a field study conducted in 366 client-owned dogs, the most common adverse reactions related to GALLIPRANT treatment were diarrhea, vomiting and inappetence. [1]

## Laboratory changes at higher doses
- In the label's safety study, serum albumin and total protein decreased with increasing doses of grapiprant [1].

## Frequently asked questions

### What is the grapiprant dose for dogs?

In a controlled field study, GALLIPRANT was given to dogs at a dose of 2 mg/kg (0.9 mg/lb) once daily for 28 days. [1]

### Can grapiprant be combined with other NSAIDs or steroids?

If additional pain medication is needed after a daily dose of GALLIPRANT, a non-NSAID/non-corticosteroid class of analgesic may be necessary. [1]

### What is the minimum age for grapiprant in dogs?

In a controlled field study, GALLIPRANT-treated dogs ranged in age from 2 to 16.75 years. [1]

### What are the most common side effects of grapiprant?

Diarrhea, vomiting and inappetence were the most common treatment-related adverse reactions [1].

## References

[1] Galliprant (grapiprant tablets) — Product Information — Drugs.com (FDA-approved label, Elanco). https://www.drugs.com/vet/galliprant.html

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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