# Tolfenamic acid for Animals: Mechanism, Doses by Species & Brands

> Tolfenamic acid is a fenamate NSAID, a structural analogue of flunixin, approved in the EU and other countries. It is used for fever, post-operative pain and inflammation in cats, dogs, cattle and…

- Source page: https://wevet.in/active-ingredients/tolfenamic-acid/
- Type: Active ingredient
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Tolfenamic acid is a fenamate NSAID, a structural analogue of flunixin, approved in the EU and other countries [1]. It is used for fever, post-operative pain and inflammation in cats, dogs, cattle and pigs [1]; the Tolfedine label dose for dogs and cats is 4 mg/kg [2].

- Class: Non-steroidal anti-inflammatory drug (NSAID, fenamate)
- Brands: Tolfedine

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Osteoarthritis pain and inflammation | 4 mg/kg [2] | SC or IM injection, then tablets | Once daily · Injection, then tablets for 2–4 more days; may be repeated once a week | Label |
| Cats | Fever | 4 mg/kg [2] | PO | Once daily · 3–5 days | Label |

## Uses

- Fever, post-operative pain and acute and chronic inflammation in cats, dogs, cattle and pigs [1].
- Dogs: osteoarthritis pain and inflammation; cats: fever (Tolfedine, Canada) [2].

## Mechanism of action

NSAIDs reduce prostaglandin production by inhibiting the cyclooxygenase (COX) enzymes [1].

## Safety

- Contraindicated with gastro-duodenal ulcers or severe kidney, heart or liver disorders, and in dehydrated, hypovolaemic or hypotensive animals [2].
- NSAIDs carry more risk in animals under 6 weeks old and in aged, debilitated or sick animals [2].


## Frequently asked questions

### What is the tolfenamic acid dose for dogs?

4 mg/kg by SC or IM injection, followed by tablets at the same dose for 2–4 more days (Tolfedine, Canada) [2].

## References

[1] Nonsteroidal Anti-inflammatory Drugs in Animals — Merck Veterinary Manual — S. H. Edwards (updated Sep 2024) (2024). https://www.merckvetmanual.com/pharmacology/inflammation/nonsteroidal-anti-inflammatory-drugs-in-animals
[2] TOLFEDINE 4% Injection — Canadian label — Drugs.com Vet — Canadian label text, Vetoquinol (2026). https://drugs.com/vet/tolfedine-4-injection-can.html

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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