# Oclacitinib for Animals: Mechanism, Doses by Species & Brands

> Oclacitinib is a synthetic Janus kinase (JAK) inhibitor for itch in dogs, given at 0.4–0.6 mg/kg twice daily for up to 14 days and then once daily.

- Source page: https://wevet.in/active-ingredients/oclacitinib/
- Type: Active ingredient
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Oclacitinib is a synthetic Janus kinase (JAK) inhibitor for itch in dogs, given at 0.4–0.6 mg/kg twice daily for up to 14 days and then once daily [1].

- Class: Janus kinase (JAK) inhibitor
- Brands: Apoquel

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Itch — first 14 days | 0.4–0.6 mg/kg [1] | PO | Twice daily · Up to 14 days | Label |
| Dogs | Itch — maintenance | 0.4–0.6 mg/kg [1] | PO | Once daily | Label |

## Uses

- Dogs at least 12 months old: pruritus of allergic dermatitis and atopic dermatitis [1].

## Mechanism of action

Oclacitinib inhibits the function of pruritogenic and pro-inflammatory cytokines that depend on JAK1 or JAK3 enzyme activity [1].

## Safety

- Not for dogs under 12 months or with serious infections [1].
- May increase susceptibility to infection, including demodicosis, and worsen neoplastic conditions [1].


## Frequently asked questions

### What is the oclacitinib dose for dogs?

0.4–0.6 mg/kg twice daily for up to 14 days, then once daily [1].

## References

[1] APOQUEL (oclacitinib) tablet — label — DailyMed (US NLM) — FDA-approved label, Zoetis (2026). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=275a2c51-9679-4f42-b8cc-21b04369a056

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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