# Fluralaner for Animals: Mechanism, Doses by Species & Brands

> Fluralaner is an isoxazoline flea and tick drug; Bravecto chews are given to dogs at a minimum of 25 mg/kg once every 12 weeks.

- Source page: https://wevet.in/active-ingredients/fluralaner/
- Type: Active ingredient
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Fluralaner is an isoxazoline flea and tick drug; Bravecto chews are given to dogs at a minimum of 25 mg/kg once every 12 weeks [1].

- Class: Isoxazoline ectoparasiticide
- Brands: Bravecto

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Fleas and ticks (Minimum dose; given as whole chews by weight band.) | 25 mg/kg [1] | PO | Every 12 weeks (every 8 weeks for lone star tick) | Label |

## Uses

- Dogs from 6 months and 4.4 lb: fleas and ticks for 12 weeks; lone star tick for 8 weeks [1].

## Mechanism of action

Fluralaner inhibits the arthropod nervous system by antagonising ligand-gated chloride channels [1].

## Safety

- Isoxazolines have been associated with neurologic adverse reactions including tremors, ataxia and seizures — use with caution in dogs with a history of seizures [1].


## Frequently asked questions

### How often is fluralaner given?

Once every 12 weeks for fleas and most ticks, or every 8 weeks where lone star ticks are a risk [1].

## References

[1] BRAVECTO (fluralaner) chewable — label — DailyMed (US NLM) — FDA-approved label, Merck Sharp & Dohme (2026). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=1fcbf232-cfd4-481e-ba9b-6251b7b468d7

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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