# Cefoperazone for Animals: Mechanism, Doses by Species & Brands

> Cefoperazone is a third-generation semi-synthetic cephalosporin with a broad spectrum of activity. In the EU it is used for intramammary treatment of clinical mastitis in lactating cattle.

- Source page: https://wevet.in/active-ingredients/cefoperazone/
- Type: Active ingredient
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Cefoperazone is a third-generation semi-synthetic cephalosporin with a broad spectrum of activity [1][2]. In the EU it is used for intramammary treatment of clinical mastitis in lactating cattle [1].

- Class: Third-generation cephalosporin (beta-lactam) antibacterial
- Brands: Gardplus

## Dose by species

## Uses

- Intramammary treatment of clinical mastitis in lactating cattle — 250 mg cefoperazone sodium per infected quarter once, or 100 mg cefoperazone dihydrate per quarter twice 24 hours apart (EU) [1].

## Mechanism of action

As a beta-lactam, it inhibits the penicillin-binding proteins and so bacterial cell wall synthesis [3]. Biliary elimination of newer cephalosporins such as cefoperazone may be appreciable [2].

## Safety

- Hypersensitivity reactions have occurred with cephalosporins, with cross-reactivity to penicillin allergies possible [2].
- Cephalosporin injections IM can be painful, and repeated IV administration may lead to local phlebitis [2].


## Frequently asked questions

### What generation is cefoperazone?

Cefoperazone is a third-generation cephalosporin [1][2].

## References

[1] Cefoperazone — Summary report (Committee for Veterinary Medicinal Products) — European Medicines Agency. https://ema.europa.eu/en/documents/mrl-report/cefoperazone-summary-report-1-committee-veterinary-medicinal-products_en.pdf
[2] Cephalosporins and Cephamycins Use in Animals — Merck Veterinary Manual (2025). https://merckvetmanual.com/pharmacology/antibacterial-agents/cephalosporins-and-cephamycins-use-in-animals
[3] Beta-lactam Antimicrobial Use in Animals — Merck Veterinary Manual (2025). https://www.merckvetmanual.com/pharmacology/antibacterial-agents/beta-lactam-antimicrobial-use-in-animals

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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