# Amoxicillin + clavulanic acid for Animals: Mechanism, Doses by Species & Brands

> Amoxicillin–clavulanate combines a bactericidal penicillin with clavulanic acid, a β-lactamase inhibitor. Clavamox chewables are dosed at 6.25 mg/lb (about 13.8 mg/kg) twice daily in dogs and 62.5 mg per cat twice daily.

- Source page: https://wevet.in/active-ingredients/amoxicillin-clavulanic-acid/
- Type: Active ingredient
- Publisher: WeVet
- Updated: 2026-11-02
- Medically reviewed by: Dr. Ravi Baraiya, B.V.Sc. (2026-11-02)
- Audience: veterinarians and veterinary students

Amoxicillin–clavulanate combines a bactericidal penicillin with clavulanic acid, a β-lactamase inhibitor [1]. Clavamox chewables are dosed at 6.25 mg/lb (about 13.8 mg/kg) twice daily in dogs and 62.5 mg per cat twice daily [1].

- Class: Penicillin antibiotic with a β-lactamase inhibitor
- Brands: Clavamox

## Dose by species

| Species | Use | Dose | Route | How often | Basis |
|---|---|---|---|---|---|
| Dogs | Skin, soft-tissue and periodontal infections (Label: 6.25 mg/lb twice a day (= 13.8 mg/kg). Label: 6.25 mg/lb (combined amoxicillin + clavulanate).) | 13.8 mg/kg [1] | PO | Twice daily · 5–7 days or 48 h after signs resolve (deep pyoderma up to 21 days); max 30 days | Label |
| Cats | Skin, soft-tissue and urinary infections (One 62.5 mg tablet per cat.) | 62.5 mg/animal [1] | PO | Twice daily · 5–7 days (UTI 10–14 days or longer); max 30 days | Label |

## Uses

- Dogs: skin and soft-tissue infections and periodontal infections [1].
- Cats: skin and soft-tissue infections and urinary tract infections (E. coli) [1].

## Mechanism of action

Amoxicillin is bactericidal and inhibits the biosynthesis of cell-wall mucopeptide; clavulanic acid inhibits β-lactamase enzymes and so extends amoxicillin's spectrum [1].

## Safety

- Contraindicated in animals with a history of allergy to any penicillin or cephalosporin [1].


## Frequently asked questions

### What is the amoxicillin–clavulanate dose for dogs?

6.25 mg/lb (about 13.8 mg/kg) of the combined product twice daily [1].

## References

[1] CLAVAMOX (amoxicillin and clavulanate potassium) chewable — label — DailyMed (US NLM) — FDA-approved label, Zoetis (2026). https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=78c3cf22-9151-4f39-a857-d103eca12c93

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Numbers in [brackets] cite the references above. For veterinary professionals. Information supports — never replaces — clinical judgement; always check the current product label and local regulations.
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